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P135

DECREASED LEFT VENTRICULAR MYOCARDIAL
PERFORMANCE IN OBSTRUCTIVE SLEEP APNEA

S. ANTIT, N. GUEDIRI, B. BEN KAAB, Y. KHELIL, A. BOUFARES, E. BOUSSABEH, M.
THAMEUR, L.ZAKHAMA
DEPARTMENT OF CARDIOLOGY, INTERIOR SECURITY FORCES HOSPITAL, LA MARSA, TUNISIA

INTRODUCTION: Obstructive sleep apnea (OSA) is associated with cardiovascular
mortality and morbidity. It may predispose patients to left ventricular hypertrophy and
heart failure.

OBJECTIVE : To determine the impact of obstructive sleep apnea (OSA) on left
ventricle (LV) structure and function and to search for a relationship between systolic
LV function and severity of OSA.

METHODES: 40 subjects without any cardiac or pulmonary disease, referred for
evaluation of OSA had overnight polysomnography and complete echocardiographic
assessment with estimation of left ventricular myocardial performance index (MPI) by
tissue Doppler method. According to apnea hypopnea index (AHI), subjects were
divided into two groups: patients with moderate OSA (AHI=15-30/h, n=18), and
patients with severe OSA (AHI ≥30/h, n=22). Were compared using ANOVA. The
correlation between OSA severity and these variables was determined with Pearson�s
correlation coefficient.

RESULTATS: There was no significant difference between the 2 groups in clinical
data. Ventricular septal and posterior wall thicknesses, LV mass index and LVend-
diastolic and end-systolic volume index were similar between the groups. Patients
with severe OSA had shorter aortic ejection times (288±32 ms vs 267±23ms; p=0.02, for
severe and no severe OSA respectively) and a higher MPI (0.61±0.14 vs 0.50±0.17;
p=0.036, respectively). A correlation was found between OSA severity and left MPI
(r=0.36, p=0.019), and aortic ejection times (r=–0.28;p=0.046).

CONCLUSIONS : MPI of left ventricle and aortic ejection time are altered in severe
OSA and are correlated to AHI severity

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