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P16

IMPACT OF SMOKING CESSATION ON THE SPIROMETRIC
PROFILE OF A POPULATION OF REGULAR CIGARETTE
SMOKERS

K. DERBEL, B. BARKOUS, A. SAYHI, S. KHALDI, F. GUEZGUEZ, S. ROUATBI
PHYSIOLOGY AND FUNCTIONAL EXPLORATION DEPARTMENT, FARHAT HACHED HOSPITAL,
SOUSSE

INTRODUCTION: Most of regular cigarette smokers (RCS) present impaired
spirometric data and are predisposed to develop COPD. Smoking cessation represent
an important part of their treatment.

OBJECTIVE: to assess the effect of smoking cessation on spirometric data of RCS.

METHODS: It was a comparative cross-sectional study that included 159 subjects
divided into two groups: G1 (RCS who quitted smoking, n=86) and and G2 (still smoking
RCS, n=73). They underwent a spirometry with measurement of first second expiratory
volume (FEV1) and FVC (forced vital capacity). Tobacco consumption was estimated
in pack years (PY) and estimated lung age was calculated with a formula using FEV1.

RESULTS: G1 and G2 were matched for sex and body mass index (7% vs 2% females,
p=0.318 and 25.6±5.9 vs 24.4±4.6 kg/m², p=0.136, respectively). In G1, median duration
of smoking cessation was 7 [3;16]. Median tobacco consumption was similar in the two
groups (45 PY in G1 vs 50 PY in G2, p=0.505). In G1, RCS were older than G2 (58±13 vs
64±10 years, p=0.002). G1 had significantly higher median FEV1 (%) and FVC (%) than
G2 (50 [33;86] vs 37 [27;55], p=0.001 and 73 [52;93] vs 61 [48;73], p=0.005, respectively).
Mean FEV1/FVC ratio was also higher in G1 (0.65±0.16 vs 0.56±0.11, p<0.001). Median
lung age was significantly more elevated in G2 (74 [52;88] in G1 vs 85 [69;94] in G2,
p=0.001).
CONCLUSION: Lung function seem to improve with smoking cessation. Therefore,
physicians should motivate RCS who are not yet willing to quit smoking.

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